Douglas E. Barrick is a professor in the Department of Biophysics at Johns Hopkins University. He earned a Ph.D. in biochemistry from Stanford University (1993) and Ph.D. in biophysics and structural biology from the University of Oregon (1996). He has been honored as recipient of the Beckman Young Investigator award, the Helen Hay Whitney Postdoctoral fellowship, and Howard Hughes Medical Institute Predoctoral Fellowship. He has been an editorial board member of the journals Protein Science and Biophysical Journal, and has been an organizer of the Gibbs Conference on Biothermodynamics. Research in his lab focuses on the study of protein evolution, folding, and assembly.

Series Preface

Preface

Acknowledgments

Note to Instructors

Author

Chapter 1 Probabilities and Statistics in Chemical and Biothermodynamics

Chapter 2 Mathematical Tools in Thermodynamics

Chapter 3 The Framework of Thermodynamics and the First Law

Chapter 4 The Second Law and Entropy

Chapter 5 Free Energy as a Potential for the Laboratory and for Biology

Chapter 6 Using Chemical Potentials to Describe Phase Transitions

Chapter 7 The Concentration Dependence of Chemical Potential, Mixing, and Reactions

Chapter 8 Conformational Equilibrium

Chapter 9 Statistical Thermodynamics and the Ensemble Method

Chapter 10 Ensembles That Interact with Their Surroundings

Chapter 11 Partition Functions for Single Molecules and Chemical Reactions

Chapter 12 The Helix-Coil Transition

Chapter 13 Ligand Binding Equilibria from a Macroscopic Perspective

Chapter 14 Ligand Binding Equilibria from a Microscopic Perspective

Appendix: How to Use Mathematica 485

Bibliography

Index