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Foreword.- Flammer syndrome in the global context - The "U-Shape" of Health Risks.- General lessons learned from Flammer syndrome.- Flammer syndrome-affected individuals may be predisposed to associated pathologies early life: Psychological and psychiatric aspects.- Flammer syndrome and eye disorders: Psychological aspects of visual impairment.- Flammer syndrome and eye disorders.- Multiomic signature of glaucoma predisposition in Flammer syndrome affected individuals - Innovative PPPM strategies in disease management.- Interrelation between Dry Mouth and Flammer Syndromes: Neglected Risks in Youth and New Concepts of Personalised Prevention.- Specific symptoms of Flammer syndrome in women suffering from vaginal dryness: individualised patient profiles, risks and mitigating measures.- Relevance of Flammer syndrome for the "Sleep-Wake" rhythm: possible mechanisms, risks and preventive strategies.- Flammer syndrome and autoimmune inflammatory conditions of the central nervous system - multifactorial interrelations.- "Young Stroke" risks may be potentially linked to the Flammer syndrome phenotype: Facts and hypotheses.- Flammer and Sjögren syndromes: What and why may be in common?- Flammer syndrome in the context of healing impairments - Facts and hypotheses for multi-professional consideration.- Feeling cold and other underestimated symptoms of Flammer syndrome in breast cancer diagnostics: Is innovative screening on the horizon?- Relevance of Flammer syndrome phenotype for metastatic breast cancer: Risks by pre-metastatic systemic hypoxic environment.- Individualised patient profile: Risk assessment by the patient's self-report and potential clinical utility of Flammer syndrome phenotype.- Triple-negative breast cancer with pronounced Flammer syndrome phenotype.- Suboptimal health status and cardiovascular deficits.- Flammer syndrome, disordered eating and microbiome: interrelations, complexity of risks and individual outcomes.- Nutritional approach to the common symptoms of Flammer syndrome.- Positive effects of acupuncture benefiting individuals with Flammer syndrome and associated pathologies.- Index.