Fundamentals of Protein NMR Spectroscopy

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Beschreibung

NMR Spectroscopy.- Practical Aspects of Acquiring NMR Spectra.- to Signal Processing.- Quantum Mechanical Description of NMR.- Quantum Mechanical Description of a One Pulse Experiment.- The Density Matrix & Product Operators.- Scalar Coupling.- Coupled Spins: Density Matrix and Product Operator Formalism.- Two Dimensional Homonuclear J-Correlated Spectroscopy.- Two Dimensional Heteronuclear J-Correlated Spectroscopy.- Coherence Editing: Pulsed-Field Gradients and Phase Cycling.- Quadrature Detection in Multi-Dimensional NMR Spectroscopy.- Resonance Assignments: Homonuclear Methods.- Resonance Assignments: Heteronuclear Methods.- Practical Aspects of N-Dimensional Data Acquisition and Processing.- Dipolar Coupling.- Protein Structure Determination.- Exchange Processes.- Nuclear Spin Relaxation and Molecular Dynamics.

Über den Autor

Professor of Biological Sciences at Carnegie Mellon University.

Professor Rule's research is directed at understanding inter-molecular interactions in biological systems. An understanding of these interactions is required if biological systems are to be comprehended at the molecular level. The combined tools of molecular biology, NMR spectroscopy and x-ray crystallography are used to provide important information to aid in our understanding of these interactions. Our research efforts have been directed at enzyme-substrate interactions, protein-lipid interactions, antibody-antigen interactions, and protein-nucleic acid interactions

Zusammenfassung

Provides a set of practical rules for many common multi-dimensional, multi-nuclear NMR pulse sequences

Offers a basis for understanding and developing novel pulse programs

Functions as a guide to many aspects of modern spectrometer hardware, sample preparation, experimental set-up, and data processing

Numerous end-of-chapter exercises help reinforce and extend fundamental concepts

Inhaltsverzeichnis

List of Figures. List of Tables.
1. Introduction To NMR Spectroscopy.
2. Acquiring One-Dimensional Spectra.
3. Processing One-Dimensional Spectra.
4. Quantum Mechanical Description Of NMR.
5. Quantum Mechanical Description Of A One Pulse Experiment.
6. The Density Matrix.
7. Scalar Coupling.
8. Density Matrix And Product Operator of Coupled Spins.
9. Two Dimensional J-Correlations.
10. Heteronuclear J-Correlation Spectroscopy.
11. Coherence Editing.
12. Quadrature Detection In two Dimensional NMR Spectroscopy.
13. Exchange Processes.
14. Nuclear Spin Relaxation.
15. Resonance Assignments: Homonuclear Methods.
16. Resonance Assignments: Heteronuclear Methods.
17. Practical Aspects of N-Dimensional Data Acquisition And Processing.
18. Dipolar Coupling.
19. Protein Structure Determination.
Appendices:
A Fourier Transforms. B Complex Variables. C Solving Simultaneous Differential Equations: Laplace Transforms.
Index.

Details

Erscheinungsjahr:	2010
Fachbereich:	Biophysik
Genre:	Biologie , Importe
Rubrik:	Naturwissenschaften & Technik
Medium:	Taschenbuch
Inhalt:	xxvi 532 S.
ISBN-13:	9789048168866
ISBN-10:	9048168864
Sprache:	Englisch
Einband:	Kartoniert / Broschiert
Autor:	Rule, Gordon S. Hitchens, T. Kevin
Hersteller:	Springer Springer Netherland
Verantwortliche Person für die EU:	Springer Verlag GmbH, Tiergartenstr. 17, D-69121 Heidelberg, juergen.hartmann@springer.com
Maße:	235 x 155 x 30 mm
Von/Mit:	Gordon S. Rule (u. a.)
Erscheinungsdatum:	19.11.2010
Gewicht:	0,838 kg