Medicinal Organometallic Chemistry

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Beschreibung

Contents: Gérard Jaouen, Nils Metzler-Nolte : Introduction ; Stéphane GIBAUD and Gérard JAOUEN: Arsenic - based drugs: from Fowler's solution to modern anticancer chemotherapy; Ana M. Pizarro, Abraha Habtemariam and Peter J. Sadler : Activation Mechanisms for Organometallic Anticancer Complexes; Angela Casini, Christian G. Hartinger, Alexey A. Nazarov, Paul J. Dyson : Organometallic antitumour agents with alternative modes of action; Elizabeth A. Hillard, Anne Vessières, Gerard Jaouen : Ferrocene functionalized endocrine modulators for the treatment of cancer; Megan Hogan and Matthias Tacke : Titanocenes - Cytotoxic and Anti-Angiogenic Chemotherapy Against Advanced Renal-Cell Cancer; Seann P. Mulcahy and Eric Meggers : Organometallics as Structural Scaffolds for Enzyme Inhibitor Design; Christophe Biot and Daniel Dive : Bioorganometallic Chemistry and Malaria; Nils Metzler-Nolte : Biomedical applications of organometal-peptide conjugates; Roger Alberto : Organometallic Radiopharmaceuticals; Brian E. Mann : Carbon Monoxide - an essential signaling molecule.

Zusammenfassung

Nils Metzler-Nolte studied chemistry in Hamburg, Freiburg and Munich, Germany. In 1994 he received his PhD for his work on synthesis, reactivity and electronic structure of alkynylboranes. After his postdoc in the laboratory of professor Green at the University of Oxford, Metzler-Nolte went to the well known Max-Planck-Institute for Bioinorganic Chemistry where he became leader of the group for bio-organometallic chemistry. Since 2000 he is professor for bioinorganic chemistry and medicinal inorganic chemistry and vice dean at the University of Heidelberg. His research is aimed at linking organometallic compounds to amino acids, small peptides and DNA analogs, namely PNAs.

Inhaltsverzeichnis

Arsenic-Based Drugs: From Fowler's Solution to Modern Anticancer Chemotherapy.- Activation Mechanisms for Organometallic Anticancer Complexes.- Organometallic Antitumour Agents with Alternative Modes of Action.- Ferrocene Functionalized Endocrine Modulators as Anticancer Agents.- Titanocenes: Cytotoxic and Anti-angiogenic Chemotherapy Against Advanced Renal-Cell Cancer.- Organometallics as Structural Scaffolds for Enzyme Inhibitor Design.- Bioorganometallic Chemistry and Malaria.- Biomedical Applications of Organometal-Peptide Conjugates.- Organometallic Radiopharmaceuticals.- Carbon Monoxide: An Essential Signalling Molecule.

Details

Erscheinungsjahr:	2012
Fachbereich:	Organische Chemie
Genre:	Chemie , Mathematik , Medizin , Naturwissenschaften , Technik
Rubrik:	Naturwissenschaften & Technik
Medium:	Taschenbuch
Inhalt:	xviii 294 S. 168 s/w Illustr. 11 farbige Illustr. 294 p. 179 illus. 11 illus. in color.
ISBN-13:	9783642264979
ISBN-10:	3642264972
Sprache:	Englisch
Herstellernummer:	978-3-642-26497-9
Einband:	Kartoniert / Broschiert
Autor:	Jaouen, Gérard Metzler-Nolte, Nils
Redaktion:	Jaouen, Gérard Metzler-Nolte, Nils
Herausgeber:	Gérard Jaouen/Nils Metzler-Nolte
Hersteller:	Springer Springer, Berlin
Verantwortliche Person für die EU:	Springer Verlag GmbH, Tiergartenstr. 17, D-69121 Heidelberg, juergen.hartmann@springer.com
Abbildungen:	XVIII, 294 p. 179 illus., 11 illus. in color.
Maße:	235 x 174 x 17 mm
Von/Mit:	Gérard Jaouen (u. a.)
Erscheinungsdatum:	05.11.2012
Gewicht:	0,476 kg