Preface

I. Setting the scene and introductory chapters

1. Distribution of the endocannabinoid system: linking signalling and development
Michaela Dvorakova and Anna Kalinovsky

2. The endocannabinoid system, immunomodulation, and LPS-induced inflammation
Elliot Lloyd, Nina Nguyen and Judith Hellman

3. Physiology of the endocannabinoid systems: imaging and the use of positron emission tomography (PET)
Claudia Poluga, Cassis Varlow, Neil Vasdev, Isabelle Boileau and Laura M. Best

4. The endocannabinoid system and aging
Prof. Vahid Reza Askari

5. The endocannabinoid system and post traumatic stress disorder (PTSD): a new narrative
Luke Ney, Kevin M. Crombie and Leah M. Mayo

II. Neurobiology of the endocannabinoid system

6. The protective effect of the endocannabinoid system in neurotoxin induced damage to hippocampal neurons: a focus on light and electron microscopy
Rita Yakovlevna Gordon, Valentina Kitchigina and Irina Mikheeva

7. Endocannabinoid Signaling and excitatory and inhibitory synapses
Jian Liang and Corette J. Wierenga

8. The endocannabinoids and potassium channels: an updated narrative
Yu-Fung Lin

9. Social interactions and neural activity: linking cellular studies and endocannabinoid signalling
Cheryl McCormick

10. Exercise and Parkinson's disease: linking in the cannabinoid type 1 (CB1) and type 2 (CB2), and mu-opioid receptors
Marucia Chacur Sr., Caroline Cristiano Real Gregório and Karina Henrique Binda

11. Endocannabinoids and inhalant misuse: neuropsychological aspects
John Woodward

12. Fatty acid amide hydrolase (FAAH) in substance use disorders: FAAH regulation and inhibition in cannabis, alcohol, nicotine, stimulant, and opioid use disorders
Garth E. Terry and Greta Niemela

13. Treatment of pain with dual fatty acid amide hydrolase (FAAH) enzyme and human soluble epoxide hydrolase (sEH) enzyme inhibitors: interlinking the endocannabinoid system
Stevan Pecic and Ram Kandasamy

14. WWL70: linking the hydrolyses 2-arachidonoylglycerol, endocannabinoid and eicosanoid pathways: therapeutic potential and neurological disease
Mikiei Tanaka and Yumin Zhang

15. Endocannabinoid catabolic enzyme inhibitors and pain alleviation
Sidney Stevens Negus and Clare Diester

16. The endocannabinoid system in health and disease: features in epilepsy
Christopher Martínez-Aguirre, Maria de los Angeles Nuñez-Lumbreras and Luisa Lilia Rocha

17. The endocannabinoid system and autoimmune demyelination: a focus on multiple sclerosis
Ana Bernal-Chico, Andres Baraibar, Alvaro Moreno-Garcia, Teresa Colomer, Ester Sanchez, Carmen Utrilla, Carlos Matute and Susana Mato

18. Endocannabinoid signaling and the lateral habenula
Jiang-Hong Ye

19. On the interplay among endocannabinoid, noradrenergic and glucocorticoid systems: evidence from aversive memory studies
Moisés Dos Santos Corrêa, Raquel Fornari, Cristina A. Stern, Leandro José Bertoglio and Lucas Gazarini

III. Receptor biology and responses

20. Adenosine A2A-cannabinoid CB1 receptor heteromers in the brain: From trans-inhibition to trans-activation
Ester Aso and Francisco Ciruela

21. Hippocampal CB1, CB2 receptors, the endocannabinoid system and fear memory
Ana Maria Raymundi and Cristina A. Stern

22. Beta-caryophyllene, the CB2 cannabinoid receptor-specific agonists and wound healing
Prof. S. Koyama and Thomas Heinbockel

23. The nigrostriatal dopaminergic pathway: impact of WIN 55212-2 as a potent cannaboinoid receptor agonist
Enzo Perez-Valenzuela and Jose Antonio Fuentealba Evans

24. Peripheral cannabinoid receptor 1 antagonists and impact on adipocytes
Morvarid Kabir

25. Endocannabinoid system receptors in plasma membranes : extraction, lipid rafts and the cortex
Changiz Taghibiglou and Hajar Miranzadeh Mahabadi

26. Applications to wound healing: cannabinoid receptor 1 antagonism and collagen deposition
Inês Correia-Sa

27. Role of the Transient Receptor Potential Vanilloid 1 (TRPV1), a component of the endocannabinoid system, in anxiety, depression, and cocaine addiction
Carmen S. Maldonado-Vlaar and Wickensonn Norze

28. Allosteric modulators of the endocannabinoid system: Org27569 and cannabinoid receptor 1 (CB1)
Dai Lu

29. Naturally occurring DELTA-9-tetrahydrocannabinol-derivatives and binding to CB1 and CB2 receptors: Linking in the endocannabinoid system
Irene Reyes-Resina, Rafael Rivas-Santisteban, Iu Raïch, Claudia Llinás del Torrent, Jaume Lillo, Rafael Franco and Gemma Navarro

IV. Profiles and behaviour of selective endocannabinoids

30. New cannabinoid receptor type 1 and 2 agonists and applications to understanding the endocannabinoid system
Manuel Faundez-Parraguez

31. Fatty acid amide hydrolase, the endocannabinoid anandamide and neurological disease
Filomena Fezza

32. The endocannabinoid-system in the immuno-biology of dendritic cells
Dipyaman Ganguly

33. Palmitoylethanolamide and other anandamide congeners in neuroinflammation-based disorders: linking in the endocannabinoid system
Enza Palazzo

34. Endocannabinoid modulation of synaptic function and behavior in the dorsomedial hypothalamus
Karen M. Crosby

35. Key role of anandamide and the endocannabinoid system in the modulation of cardio-renal homeostasis
Prof. Virna M. Martín Gimenez and Walter Manucha

36. The endocannabinoid system: Signaling and social motivation
Roberta Monterazzo Cysneiros and Fernanda Ribeiro

V. Exogenous, synthetic other compounds linking in the endocannabinoid system

37. Safety and toxicology of the dietary cannabinoid beta-caryophyllene
Prof. George Oliveira Sr., Bruna Silva, Ana Santos C. L. da Silva and Luciano Silva Lopes

38. Synthetic cannabimimetics: an overview
Prof. M. Kassiou

VI. Compartive studies in non neurological systems

39. Non Neurological Aspects of the¿ Endocannabinoid System: Non Alcoholic Fatty Liver Disease
Dr. R. Ghazali

40. Components of the Endocannabinoid system: Hepatic expression levels of the cannabinoid receptors and microRNAs
Sema Bolkent and Zeynep Mine Coskun

41. Tumour growth and the endocannabinoid system: investigating CB2 agonists
Josee Guindon, Isabel Castro-Piedras, Melissa McHann and Robert Barnes

42. Linking Endocannabinoid System, Palmitoylethanolamide and Sarcopenia in view of therapeutic outcomes
Susanna Molinari, Eleonora Maretti, Renata Battini and Eliana Leo

VII. Resources

43. Endocannabinoids and Resources
Rajkumar Rajendram