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Pharmaceutical Inhalation Aerosol Technology, Third Edition
Taschenbuch von Anthony J. Hickey (u. a.)
Sprache: Englisch

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Beschreibung
This fully revised and updated third edition of Pharmaceutical Inhalation Aerosol Technology encompasses the scientific and technical foundation for the rationale, design, componentry, assembly and quality performance metrics of therapeutic inhalers in their delivery of pharmaceutical aerosols to treat symptoms or the underlying causes of disease. It focuses on the importance of pharmaceutical engineering as a foundational element of all inhaler products and their application to pulmonary drug delivery. The expanded scope considers previously unaddressed aspects of pharmaceutical inhalation aerosol technology and the patient interface by including aerosol delivery, lung deposition and clearance that are used as measures of effective dose delivery.

Key Features:





  • Provides a thoroughly revised and expanded reference with authoritative discussions on the physiologic,pharmacologic, metabolic, molecular, cellular and physicochemical factors, influencing the efficacy and utilization of pharmaceutical aerosols




  • Emphasizes the importance of pharmaceutical engineering as a foundational element of all inhaler products and their application to pulmonary drug delivery




  • Addresses the physics, chemistry and engineering principles while establishing disease relevance




  • Expands the 'technology' focus of the original volumes to address the title more directly




  • Offers an impressive breadth of coverage as well as an international flavour from outstanding editors and contributors
This fully revised and updated third edition of Pharmaceutical Inhalation Aerosol Technology encompasses the scientific and technical foundation for the rationale, design, componentry, assembly and quality performance metrics of therapeutic inhalers in their delivery of pharmaceutical aerosols to treat symptoms or the underlying causes of disease. It focuses on the importance of pharmaceutical engineering as a foundational element of all inhaler products and their application to pulmonary drug delivery. The expanded scope considers previously unaddressed aspects of pharmaceutical inhalation aerosol technology and the patient interface by including aerosol delivery, lung deposition and clearance that are used as measures of effective dose delivery.

Key Features:





  • Provides a thoroughly revised and expanded reference with authoritative discussions on the physiologic,pharmacologic, metabolic, molecular, cellular and physicochemical factors, influencing the efficacy and utilization of pharmaceutical aerosols




  • Emphasizes the importance of pharmaceutical engineering as a foundational element of all inhaler products and their application to pulmonary drug delivery




  • Addresses the physics, chemistry and engineering principles while establishing disease relevance




  • Expands the 'technology' focus of the original volumes to address the title more directly




  • Offers an impressive breadth of coverage as well as an international flavour from outstanding editors and contributors
Inhaltsverzeichnis
Introduction

Discovery - pharmacology and physiology



Aerosol critical attributes - aerodynamic behavior, lung deposition and clearance



Active Pharmaceutical Ingredient/Drug Product manufacturing



Particle Engineering and Processing - milling, blending, spray drying, supercritical fluid, nano



Drug Product Formulation



Devices - design and performance



Drug Product Formulation



Product testing - physico-chemical properties, aerodynamic particle size, delivered dose



Regulatory considerations - CMC



Preclinical testing - dosing for cells and animals



Clinical testing - concepts of bioequivalence



General Conclusion

Details
Medium: Taschenbuch
ISBN-13: 9781032093222
ISBN-10: 1032093226
Sprache: Englisch
Redaktion: Hickey, Anthony J.
da Rocha, Sandro R.
Auflage: 3. Aufl.
Hersteller: CRC Press
Taylor & Francis
Verantwortliche Person für die EU: preigu, Ansas Meyer, Lengericher Landstr. 19, D-49078 Osnabrück, mail@preigu.de
Abbildungen: 200 SW-Abb.
Maße: 39 x 178 x 254 mm
Von/Mit: Anthony J. Hickey (u. a.)
Erscheinungsdatum: 30.06.2021
Gewicht: 1,301 kg
Artikel-ID: 120292528
Inhaltsverzeichnis
Introduction

Discovery - pharmacology and physiology



Aerosol critical attributes - aerodynamic behavior, lung deposition and clearance



Active Pharmaceutical Ingredient/Drug Product manufacturing



Particle Engineering and Processing - milling, blending, spray drying, supercritical fluid, nano



Drug Product Formulation



Devices - design and performance



Drug Product Formulation



Product testing - physico-chemical properties, aerodynamic particle size, delivered dose



Regulatory considerations - CMC



Preclinical testing - dosing for cells and animals



Clinical testing - concepts of bioequivalence



General Conclusion

Details
Medium: Taschenbuch
ISBN-13: 9781032093222
ISBN-10: 1032093226
Sprache: Englisch
Redaktion: Hickey, Anthony J.
da Rocha, Sandro R.
Auflage: 3. Aufl.
Hersteller: CRC Press
Taylor & Francis
Verantwortliche Person für die EU: preigu, Ansas Meyer, Lengericher Landstr. 19, D-49078 Osnabrück, mail@preigu.de
Abbildungen: 200 SW-Abb.
Maße: 39 x 178 x 254 mm
Von/Mit: Anthony J. Hickey (u. a.)
Erscheinungsdatum: 30.06.2021
Gewicht: 1,301 kg
Artikel-ID: 120292528
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